Novel simple thioureas with growth hormone releasing properties

被引：3

作者：

Ankersen, M ^{[1
]}

Hansen, BS ^{[1
]}

机构：

[1] NOVO NORDISK AS,DK-2880 BAGSVAERD,DENMARK

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 7-8期

关键词：

growth hormone secretagogue; thiourea; GHRP-6; GHRP-2; L-629,429, MK-0677;

D O I：

10.1016/S0223-5234(97)83289-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of thioureas containing two aromatic groups and one amino group was synthesized as potential growth hormone secretagogues. The growth hormone (GH) releasing properties of these compounds (10-24) were evaluated using primary rat pituitary cells. The most potent compound 20 showed potency with an EC50 of 1.8 mu M. Two constrained analogs 23 and 24 showed similar activity.

引用

页码：631 / 635

页数：5

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