Neurosteroids mediate pharmacological effects of ethanol: A new mechanism of ethanol action?

被引:113
作者
Morrow, AL
Janis, GC
VanDoren, MJ
Matthews, DB
Samson, HH
Janak, PH
Grant, KA
机构
[1] Univ N Carolina, Sch Med, Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Psychiat, Curriculum Neurobiol, Chapel Hill, NC 27515 USA
[3] Univ N Carolina, Dept Pharmacol, Curriculum Neurobiol, Chapel Hill, NC 27515 USA
[4] Wake Forest Univ, Sch Med, Ctr Neurobeh Study Alchol, Winston Salem, NC 27109 USA
关键词
D O I
10.1111/j.1530-0277.1999.tb04094.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
引用
收藏
页码:1933 / 1940
页数:8
相关论文
共 83 条
[1]   ACUTE AND CHRONIC ETHANOL TREATMENTS ALTER GABA RECEPTOR-OPERATED CHLORIDE CHANNELS [J].
ALLAN, AM ;
HARRIS, RA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (04) :665-670
[2]   DRUG DISCRIMINATION ANALYSIS OF ENDOGENOUS NEUROACTIVE STEROIDS IN RATS [J].
ATOR, NA ;
GRANT, KA ;
PURDY, RH ;
PAUL, SM ;
GRIFFITHS, RR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 241 (2-3) :237-243
[3]   NEUROSTEROIDS IN THE BRAIN OF HANDLING-HABITUATED AND NAIVE RATS - EFFECT OF CO2 INHALATION [J].
BARBACCIA, ML ;
ROSCETTI, G ;
TRABUCCHI, M ;
CUCCHEDDU, T ;
CONCAS, A ;
BIGGIO, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 261 (03) :317-320
[4]   The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations [J].
Barbaccia, ML ;
Roscetti, G ;
Trabucchi, M ;
Purdy, RH ;
Mostallino, MC ;
Concas, A ;
Biggio, G .
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 (08) :1582-1588
[5]   Time-dependent changes in rat brain neuroactive steroid concentrations and GABA(A) receptor function after acute stress [J].
Barbaccia, ML ;
Roscetti, G ;
Trabucchi, M ;
Mostallino, MC ;
Concas, A ;
Purdy, RH ;
Biggio, G .
NEUROENDOCRINOLOGY, 1996, 63 (02) :166-172
[6]   ANTICONVULSANT PROFILE OF THE PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE [J].
BELELLI, D ;
BOLGER, MB ;
GEE, KW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (02) :325-329
[7]   Discriminative stimulus properties of ethanol in the rat: Effects of neurosteroids and picrotoxin [J].
Bienkowski, P ;
Kostowski, W .
BRAIN RESEARCH, 1997, 753 (02) :348-352
[8]  
BIGGIO G, 1996, BRAIN SOURCE TARGET, P43
[9]   ANXIOLYTIC EFFECTS OF 3A-HYDROXY-5A[BETA]-PREGNAN-20-ONE - ENDOGENOUS METABOLITES OF PROGESTERONE THAT ARE ACTIVE AT THE GABA-A RECEPTOR [J].
BITRAN, D ;
HILVERS, RJ ;
KELLOGG, CK .
BRAIN RESEARCH, 1991, 561 (01) :157-161
[10]  
Bowen CA, 1999, J PHARMACOL EXP THER, V289, P405