Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa

被引:32
作者
Garrido, L [1 ]
Zubía, E [1 ]
Ortega, MJ [1 ]
Salvá, J [1 ]
机构
[1] Univ Cadiz, Fac Ciencias Mar, Dept Quim Organ, Puerto Real 11510, Cadiz, Spain
关键词
gorgonian; Leptogorgia sarmentosa; cytotoxicity;
D O I
10.1016/S0039-128X(99)00083-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 mu g/ml). (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:85 / 88
页数:4
相关论文
共 10 条
[1]   4 NEW BIOACTIVE POLYHYDROXYLATED STEROLS FROM THE BLACK CORAL ANTIPATHES-SUBPINNATA [J].
AIELLO, A ;
FATTORUSSO, E ;
MENNA, M .
JOURNAL OF NATURAL PRODUCTS, 1992, 55 (03) :321-325
[2]   5 NEW POLAR STEROLS FROM THE BLACK CORAL ANTIPATHES-SUBPINNATA [J].
AIELLO, A ;
FATTORUSSO, E ;
MENNA, M .
STEROIDS, 1991, 56 (10) :513-517
[3]   GUGGULSTEROL-LIKE STEROIDS FROM THE MEDITERRANEAN GORGONIAN LEPTOGORGIA-SARMENTOSA [J].
BENVEGNU, R ;
CIMINO, G ;
DEROSA, S ;
DESTEFANO, S .
EXPERIENTIA, 1982, 38 (12) :1443-1444
[4]  
Breitmaier E, 1989, CARBON 13 NMR SPECTR, P340
[5]   CHOLEST-4, 14-DIEN-15, 20-XI-DIOL-3, 16-DIONE, A NOVEL POLYOXYGENATED MARINE STEROID WHICH EASILY LOSES THE SIDE-CHAIN [J].
CIMINO, G ;
DEROSA, S ;
DESTEFANO, S ;
SCOGNAMIGLIO, G ;
SODANO, G .
TETRAHEDRON LETTERS, 1981, 22 (31) :3013-3016
[6]   C-18 HYDROXY STEROIDS FROM THE MEDITERRANEAN GORGONIAN LEPTOGORGIA-SARMENTOSA [J].
CIMINO, G ;
DEROSA, S ;
DESTEFANO, S ;
SODANO, G .
EXPERIENTIA, 1984, 40 (03) :246-248
[7]   POLYOXYGENATED STEROIDS OF MARINE ORIGIN [J].
DAURIA, MV ;
MINALE, L ;
RICCIO, R .
CHEMICAL REVIEWS, 1993, 93 (05) :1839-1895
[8]  
Faulkner DJ, 1999, NAT PROD REP, V16, P155
[9]   CONFORMATIONAL-ANALYSIS OF 17(20) BOND OF 20-KETO STEROIDS [J].
NES, WR ;
VARKEY, TE .
JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (09) :1652-1653
[10]   (Z)-17(20)-DEHYDROCHOLESTEROL - NEW STEROL WITH C-21 AND C-22 SPATIALLY FIXED [J].
NES, WR ;
VARKEY, TE ;
CRUMP, DR ;
GUT, M .
JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (21) :3429-3433