Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa

被引：32

作者：

Garrido, L ^{[1
]}

Zubía, E ^{[1
]}

Ortega, MJ ^{[1
]}

Salvá, J ^{[1
]}

机构：

[1] Univ Cadiz, Fac Ciencias Mar, Dept Quim Organ, Puerto Real 11510, Cadiz, Spain

来源：

STEROIDS | 2000年 / 65卷 / 02期

关键词：

gorgonian; Leptogorgia sarmentosa; cytotoxicity;

D O I：

10.1016/S0039-128X(99)00083-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 mu g/ml). (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：85 / 88

页数：4

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