Stable neurological function in subjects treated with 2'3'-dideoxyinosine

被引：7

作者：

Sidtis, JJ

Dafni, U

Slasor, P

Hall, C

Price, RW

Kieburtz, K

Tucker, T

Clifford, DB

机构：

[1] WASHINGTON UNIV, DEPT NEUROL & NEUROL SURG, ST LOUIS, FRANCE

[2] UNIV MINNESOTA, DEPT NEUROL, MINNEAPOLIS, MN 55455 USA

[3] HARVARD UNIV, SCH PUBL HLTH, BOSTON, MA 02115 USA

[4] UNIV N CAROLINA, DEPT NEUROL, CHAPEL HILL, NC USA

[5] UNIV ROCHESTER, DEPT NEUROL, ROCHESTER, NY USA

[6] CASE WESTERN RESERVE UNIV, DEPT NEUROL, CLEVELAND, OH 44106 USA

来源：

JOURNAL OF NEUROVIROLOGY | 1997年 / 3卷 / 03期

关键词：

DDI; didanosine; zidovudine; acquired immunodeficiency syndrome; AIDS dementia; HIV; AIDS DEMENTIA COMPLEX; HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; ZIDOVUDINE AZT; CONTROLLED TRIAL; FOLLOW-UP; INFECTION; DIDANOSINE; PHARMACOKINETICS; INTOLERANT;

D O I：

10.3109/13550289709018299

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'-dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.

引用

页码：233 / 240

页数：8

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