New insights into the pathophysiology of nonalcoholic fatty liver disease

被引：18

作者：

Chavez-Tapia, Norberto C. ^{[3
]}

Uribe, Misael ^{[1
,2
,3
]}

Ponciano-Rodriguez, Guadalupe ^{[4
]}

Medina-Santillan, Roberto ^{[5
]}

Mendez-Sanchez, Nahum ^{[1
,2
]}

机构：

[1] Med Clin & Fdn, Dept Biomed Res, Gastroenterol & Liver Unit, Mexico City, DF, Mexico

[2] Med Clin & Fdn, Liver Unit, Mexico City, DF, Mexico

[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico

[4] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico

[5] IPN, Escuela Super Med, Secc Estudios Postgrad & Invest, Mexico City 07738, DF, Mexico

来源：

ANNALS OF HEPATOLOGY | 2009年 / 8卷

关键词：

Fatty acids; immune response; vagus nerve; steatosis; insulin resistance; HIGH-MOLECULAR-WEIGHT; INDUCED INSULIN-RESISTANCE; TUMOR-NECROSIS-FACTOR; METABOLIC SYNDROME; HEPATIC STEATOSIS; IN-VIVO; STEATOHEPATITIS; ADIPONECTIN; GLUCOSE; RECEPTOR;

D O I：

10.1016/S1665-2681(19)31821-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The consequences of pathologic adipose tissue accumulation have been described for almost all organs. Nonalcoholic fatty liver disease (NAFLD) is considered the most relevant hepatic manifestation of obesity. There is great interest in the study of NAFLD, and new insights into its pathogenic process have been described. Currently, in addition to insulin resistance, which was considered the hallmark of this disease, endocrine, immunologic, and central nervous system factors are attracting interest as explanatory variables. In this review, new factors associated with the main theories on the pathophysiology of NAFLD are analyzed.

引用

页码：S9 / S17

页数：9

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