Distribution of Ca2+ extrusion sites on the mouse pancreatic acinar cell surface

被引：25

作者：

Belan, P ^{[1
]}

Gerasimenko, O ^{[1
]}

Petersen, OH ^{[1
]}

Tepikin, AV ^{[1
]}

机构：

[1] AA BOGOMOLETS PHYSIOL INST,UA-252601 KIEV,UKRAINE

来源：

CELL CALCIUM | 1997年 / 22卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0143-4160(97)90084-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The localizations of Ca2+ extrusion sites in mouse pancreatic acinar cells during elevation of the intracellular free calcium concentration ([Ca2+](i)) have been studied. During an agonist stimulated calcium elevation as well as when intracellular calcium is released from a 'caged compound', Ca2+ is primarily extruded from the apical secretory pole of the cells in spite of different spatial patterns of [Ca2+](i), different sources of Ca2+, and the presence or absence of agonist, This is most likely due to a relatively high density of calcium pumps in the secretory granule region, although it could be explained by calcium pumps in this part of the cell having different characteristics from those in the basal membrane. The intensity of Ca2+ extrusion in the apical secretory pole is such that substantial (several millimoles per litre) changes of the free calcium concentration in the lumen of the acinus can occur during agonist stimulation.

引用

页码：5 / 10

页数：6

共 14 条

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