Rhodiolosides A-E, monoterpene glycosides from Rhodiola rosea

被引:45
作者
Ma, Guizhi
Li, Wei
Dou, Deqiang
Chang, Xiaolong
Bai, Hong
Satou, Tadaaki
Li, Jun
Sun, Dianjia
Kang, Tingguo
Nikaido, Tamotsu
Koike, Kazuo
机构
[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
[2] Xinjiang Med Univ, Coll Pharm, Urumki 830054, Peoples R China
[3] Liaoning Univ Tradit Chinese Med, Coll Pharm, Shenyang 110032, Peoples R China
关键词
Rhodiola rosea; Crassulaceae; monoterpene; glycoside; rhodioloside;
D O I
10.1248/cpb.54.1229
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Five new monoterpene glycosides, rhodiolosides A-E (1-5), were isolated from the roots of Rhodiola rosea (Crassulaceae). Their structures were elucidated as (2E,6E,4R)-4,8-dihydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranoside (1), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranosyl(1 -> 6)-beta-D-glucopyranoside (2), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranosyl(1 -> 3)-beta-D-glucopyranoside (3), (2E,4R)-4,7-dihydroxy-3,7-dimethyl-2-octenyl beta-D-glucopyranoside (4), and (2E)-7-hydroxy-3,7-dimethyl-2-octenyl alpha-L-arabinopyranosyl(1 -> 6)-beta-D-glucopyranoside (5), on the basis of various spectroscopic analyses and chemical degradation.
引用
收藏
页码:1229 / 1233
页数:5
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