Palladium-catalyzed synthesis of N-aryl pyrrolidines from γ-(N-arylamino) alkenes:: Evidence for chemoselective alkene insertion into Pd-N bonds

被引：159

作者：

Ney, JE ^{[1
]}

Wolfe, JP ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 27期

关键词：

alkene insertion; aryl halides; diastereoselectivity; nitrogen heterocycles; palladium;

D O I：

10.1002/anie.200460060

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The formation of a C-C and a C-N bond in a reaction between γ-(N-arylamino) alkenes and aryl bromides results in the stereoselective synthesis of substituted pyrrolidine derivatives (see scheme). Preliminary studies suggest these reactions proceed by intramolecular alkene insertion into the Pd-N bond of intermediate [Pd(Ar)(amido)] complexes. dba = dibenzylideneacetone, dppb = 1,3-bis(diphenylphosphanyl) butane.

引用

页码：3605 / 3608

页数：4

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