Modulating mighty microglia

被引：24

作者：

Block, Michelle L. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Stark Neurosci Res Inst, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

来源：

NATURE CHEMICAL BIOLOGY | 2014年 / 10卷 / 12期

关键词：

DISEASE;

D O I：

10.1038/nchembio.1691

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The small molecule inflachromene was discovered as a microglia-selective inhibitor of the central nervous system proinflammatory response and found to target HMGB2 and HMGB1 to impair proinflammatory signaling in microglia, resulting in neuroprotection.

引用

页码：988 / 989

页数：3

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