Calcimimetic agents and the calcium-sensing receptor

被引：21

作者：

Coburn, JW

Maung, HM

机构：

[1] VA W Los Angeles Healthcare Ctr, Nephrol Sect 111L, Med Serv, Los Angeles, CA 90073 USA

[2] VA W Los Angeles Healthcare Ctr, Res Serv, Los Angeles, CA 90073 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 02期

关键词：

D O I：

10.1097/00041552-200003000-00005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Blood ionized extracellular calcium is closely regulated. To accomplish this, a hormone-like receptor that is responsive to extracellular ionized calcium regulates both the secretion of parathyroid hormone and the excretion of urinary calcium (as well as other cellular processes). Several hereditary disorders have mutations that cause either loss or gain of function of the calcium-sensing receptor, and alterations of the calcium-sensing receptor may play a role in both primary and secondary hyperparathyroidism. Calcimimetics are agents that act to make the calcium-sensing receptor more sensitive to extracellular ionized calcium; thereby they suppress the secretion of parathyroid hormone. Early trials in animal models of secondary hyperparathyroidism and in patients with primary hyperparathyroidism or with uremic secondary hyperparathyroidism have shown that the first generation calcimimetic, R-568, effectively lowers parathyroid hormone levels and is well tolerated. Curr Opin Nephrol Hypertens 9:123-132. (C) 2000 Lippincott Williams & Wilkins.

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页码：123 / 132

页数：10

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