CpG oligonucleotides accelerate and boost the immune response elicited by AVA, the licensed anthrax vaccine

被引：21

作者：

Klinman, Dennis M. ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

来源：

EXPERT REVIEW OF VACCINES | 2006年 / 5卷 / 03期

关键词：

adjuvant; anthrax; CpG oligonucleotide; protection; vaccine;

D O I：

10.1586/14760584.5.3.365

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the immune response elicited by coadministered vaccines. Combining CpG ODN with anthrax vaccine adsorbed (AVA), the licensed human vaccine, can increase the speed, magnitude and avidity of the resultant anti-anthrax response in mice, rhesus macaques and humans. Adsorbing the CpG ODN onto cationic poly(actide-coglycolides) microparticles further boosts immunity to coadministered AVA. The antibody response induced by CpG ODN plus AVA confers protection against systemic anthrax challenge in multiple animal models. These findings suggest that CpG ODN, alone or in combination with other adjuvants and delivery strategies, may support the development of prophylactic and therapeutic vaccines against biothreat pathogens.

引用

页码：365 / 369

页数：5

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