The macrophage marches on its phagosome: dynamic assays of phagosome function

被引:139
作者
Russell, David G. [1 ]
VanderVen, Brian C. [1 ]
Glennie, Sarah [2 ]
Mwandumba, Henry [3 ]
Heyderman, Robert S. [2 ]
机构
[1] Cornell Univ, Dept Microbiol & Immunol, Coll Vet Med, Ithaca, NY 14853 USA
[2] Queen Elizabeth Hosp, Malawi Liverpool Wellcome Trust Labs, Blantyre, Malawi
[3] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3GE, Merseyside, England
基金
美国国家卫生研究院; 英国惠康基金;
关键词
REAL-TIME; MATURATION; ACTIVATION; SIGNALS; PHOSPHATIDYLSERINE; PHAGOCYTOSIS; RECOGNITION; COOPERATION; MODULATION; PROTEOME;
D O I
10.1038/nri2591
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes. Moreover, phagocytes have also acquired an active role in microbial killing. This Innovation article describes new assays that probe the biological activities which occur within phagosomes. These assays provide functional insights into how the phagosome fulfils its diverse roles in homeostasis and in innate and adaptive immune responses.
引用
收藏
页码:594 / U84
页数:7
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