Comparison of CO2 in air versus carbogen for the measurement of cerebrovascular reactivity with magnetic resonance imaging

被引:36
作者
Hare, Hannah V. [1 ,2 ]
Germuska, Michael [1 ]
Kelly, Michael E. [1 ]
Bulte, Daniel P. [1 ]
机构
[1] Univ Oxford, FMRIB Ctr, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England
[2] Univ Oxford, Dept Phys, Oxford OX3 9DU, England
基金
英国工程与自然科学研究理事会;
关键词
arterial spin labeling; ASL; BOLD contrast; cerebral blood flow measurement; cerebral hemodynamics; MRI; CEREBRAL-BLOOD-FLOW; OXIDATIVE-METABOLISM; MAJOR DEPRESSION; CALIBRATED MRI; BOLD FMRI; 3.0; TESLA; DISEASE; HYPERCAPNIA; DIOXIDE; ALZHEIMERS;
D O I
10.1038/jcbfm.2013.131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Measurement of cerebrovascular reactivity (CVR) can give valuable information about existing pathology and the risk of adverse events, such as stroke. A common method of obtaining regional CVR values is by measuring the blood flow response to carbon dioxide (CO2)-enriched air using arterial spin labeling (ASL) or blood oxygen level-dependent (BOLD) imaging. Recently, several studies have used carbogen gas (containing only CO2 and oxygen) as an alternative stimulus. A direct comparison was performed between CVR values acquired by ASL and BOLD imaging using stimuli of (1) 5% CO2 in air and (2) 5% CO2 in oxygen (carbogen-5). Although BOLD and ASL CVR values are shown to be correlated for CO2 in air (mean response 0.11 +/- 0.03% BOLD, 4.46 +/- 1.80% ASL, n=16 hemispheres), this correlation disappears during a carbogen stimulus (0.36 +/- 0.06% BOLD, 4.97 +/- 1.30% ASL). It is concluded that BOLD imaging should generally not be used in conjunction with a carbogen stimulus when measuring CVR, and that care must be taken when interpreting CVR as measured by ASL, as values obtained from different stimuli (CO2 in air versus carbogen) are not directly comparable.
引用
收藏
页码:1799 / 1805
页数:7
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