Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses

被引：89

作者：

Adedeji, Adeyemi O. ^{[1
,2
]}

Singh, Kamalendra ^{[1
,2
]}

Kassim, Ademola ^{[1
,2
]}

Coleman, Christopher M. ^{[3
]}

Elliott, Ruth ^{[4
]}

Weiss, Susan R. ^{[4
]}

Frieman, Matthew B. ^{[3
]}

Sarafianos, Stefan G. ^{[1
,2
,5
]}

机构：

[1] Univ Missouri, Christopher Bond Life Sci Ctr, Columbia, MO 65211 USA

[2] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA

[3] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[4] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[5] Univ Missouri, Dept Biochem, Columbia, MO USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1128/AAC.02994-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have previously shown that SSYA10-001 blocks severe acute respiratory syndrome coronavirus (SARS-CoV) replication by inhibiting SARS-CoV helicase (nsp13). Here, we show that SSYA10-001 also inhibits replication of two other coronaviruses, mouse hepatitis virus (MHV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). A putative binding pocket for SSYA10-001 was identified and shown to be similar in SARS-CoV, MERS-CoV, and MHV helicases. These studies show that it is possible to target multiple coronaviruses through broad-spectrum inhibitors.

引用

页码：4894 / 4898

页数：5

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