Facile synthesis of tetrahydroquinolines and julolidines through multicomponent reaction

被引：49

作者：

Legros, Julien ^{[1
]}

Crousse, Benoit ^{[1
]}

Ourevitch, Michele ^{[1
]}

Bonnet-Delpon, Daniele ^{[1
]}

机构：

[1] Fac Pharm Paris, CNRS, Lab BioCIS, F-92296 Chatenay Malabry, France

来源：

SYNLETT | 2006年 / 12期

关键词：

domino reaction; cycloaddition; fluorous alcohols; heterocycles; solvent effect;

D O I：

10.1055/s-2006-947360

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehydes, anilines and enol ethers react in trifluoroethanol (TFE) through an aza-Diels-Alder reaction (Povarov reaction) to afford the corresponding substituted tetrahydroquinolines. This reaction occurs, without any catalyst, under sequential three-component conditions, allowing thus the use of aliphatic aldehydes. In the presence of formaldehyde and an excess of dienophile, the product undergoes a second Povarov reaction affording new julolidine derivatives.

引用

页码：1899 / 1902

页数：4

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