Parity and secondary progression in multiple sclerosis

被引：62

作者：

Koch, M. ^{[1
]}

Uyttenboogaart, M. ^{[1
]}

Heersema, D. ^{[1
]}

Steen, C. ^{[1
]}

De Keyser, J. ^{[1
,2
]}

机构：

[1] Univ Groningen, Dept Neurol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[2] Vrije Univ Brussel, Dept Neurol, UZ Brussel, Brussels, Belgium

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2009年 / 80卷 / 06期

关键词：

NATURAL-HISTORY; PREGNANCY; DISABILITY; DISEASE; PHASE; RISK;

D O I：

10.1136/jnnp.2008.160911

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression. Objective: To investigate the association of parity and secondary progression in women with MS. Methods: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders. Results: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression. Conclusion: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.

引用

页码：676 / 678

页数：3

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