Molecular studies of the aetiology of trisomy 8 in spontaneous abortions and the liveborn population

被引：47

作者：

James, RS

Jacobs, PA

机构：

[1] Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury

来源：

HUMAN GENETICS | 1996年 / 97卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/BF02185754

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have determined the parental origin in eight cases of constitutional trisomy 8. In all four cases of spontaneous abortion, the additional chromosome was maternal in origin and there was evidence for nullichiasmate meiosis I occurring in the genesis of this trisomy. In contrast, all four cases of liveborn trisomy 8 appear to have arisen by a mechanism consistent with the post-zygotic mitotic gain of the additional chromosome.

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页码：283 / 286

页数：4

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