Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice

被引：61

作者：

Miura, T

Itoh, Y

Kaneko, T

Ueda, N

Ishida, T

Fukushima, M

Matsuyama, F

Seino, Y

机构：

[1] Suzuka Univ Med Sci, Dept Clin Nutr, Suzuka, Mie 5100293, Japan

[2] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan

[3] Kyoto Univ, Fac Med, Dept Metab & Clin Nutr, Sakyo Ku, Kyoto 6068507, Japan

[4] Use Techno Corp Co Ltd, Kyoto 6200055, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 07期

关键词：

corosolic acid; glucose transporter (GLUT) 4; translocation; hypoglycemic effect; type; 2; diabetes;

D O I：

10.1248/bpb.27.1103

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally CA-treated mice when compared with that of the controls (p<0.05). These results suggest that the hypoglycemic effect of CA is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that CA has beneficial effects on hyperglycemia in type 2 diabetes.

引用

页码：1103 / 1105

页数：3

共 21 条

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