Risk Factors for Respiratory Failure Associated with Respiratory Syncytial Virus Infection in Adults

被引：69

作者：

Duncan, Coley B. ^{[1
,2
]}

Walsh, Edward E. ^{[1
,2
]}

Peterson, Derick R. ^{[3
]}

Lee, F. Eun-Hyung ^{[4
]}

Falsey, Ann R. ^{[1
,2
]}

机构：

[1] Rochester Gen Hosp, Dept Med, Rochester, NY 14621 USA

[2] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA

[3] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY USA

[4] Univ Rochester, Sch Med & Dent, Div Pulm & Crit Care Med, Rochester, NY USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 08期

关键词：

DISEASE SEVERITY; HOSPITALIZED INFANTS; ELDERLY ADULTS; EPIDEMIOLOGY; ANTIBODY; LOAD;

D O I：

10.1086/605948

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Risk factors associated with respiratory failure during respiratory syncytial virus (RSV) infection have not been assessed in adults. We identified RSV by quantitative reverse transcription polymerase chain reaction in 58 adults during the 2007-2008 winter. Clinical variables and respiratory secretion viral loads were compared in 26 outpatients and 32 inpatients. Cardiopulmonary diseases were more common among inpatients than outpatients (91% vs 31%, P = .0001), whereas mean RSV load was similar. Nasal viral load was higher in ventilated vs nonventilated hospitalized patients (log(10) 3.7 +/- 1.7 plaque-forming units (PFUs)/mL vs 2.4 +/- 1.1 PFUs/mL, P = .02), and high viral load was independently associated with respiratory failure.

引用

页码：1242 / 1246

页数：5

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