Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke

被引：32

作者：

Zacharek, Alex

Chen, Jieli

Zhang, Chunling

Cui, Xu

Roberts, Cynthia

Jiang, Hao

Teng, Hua

Chopp, Michael

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI 48309 USA

来源：

NEUROSCIENCE LETTERS | 2006年 / 404卷 / 1-2期

关键词：

angiogenesis; DETA-NONOate; Angiopoietin; 1; Tie2; Occludin; stroke;

D O I：

10.1016/j.neulet.2006.05.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We tested whether the nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA-NONOate), increases expression of Angiopoietin (Ang1)/Fie2, which may playa role in regulating angliogenesis and vascular integrity after stroke in rats. Wistar rats were subjected to middle cerebral artery occlusion and treated with or without DETA-NONOate. Stroke rats treated with DETA-NONOate show significantly increased Ang1, Tic2 and Occludin expression in the ischemic border compared with control stroke animals (P < 0.05). Consistent with in vivo data, DETA-NONOate promotes capillary tube formation in cultured brain endothelial cells. Neutralizing Angl antibody attenuates DETA-NONOate-induced capillary tube formation. The data suggest that the Ang1/Tie2 axis promotes DETA-NONOate-induced angiogenesis and stabilizes of angiogenic vessels after stroke. (c) 2006 Published by Elsevier Ireland Ltd.

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页码：28 / 32

页数：5

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