Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

被引：25

作者：

Gloster, TM

Williams, SJ

Roberts, S

Tarling, CA

Wicki, J

Withers, SG

Davies, GJ ^{[1
]}

机构：

[1] Univ York, Dept Chem, Struct Biol Lab, Heslington YO10 5YW, England

[2] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[3] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 16期

关键词：

D O I：

10.1039/b405152a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The atomic resolution structures of xylobiose-derived isofagomine and xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A from Streptomyces lividans reveal undistorted C-4(1) chair conformed sugars and, in the case of the deoxynojirimycin analogue, suggest unusual pK(a) changes of the enzyme's catalytic machinery upon binding.

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页码：1794 / 1795

页数：2

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