Analyses of Chloramphenicol in Biological Samples by HPLC

被引：24

作者：

Ali, Imran ^{[2
]}

Aboul-Enein, Hassan Y. ^{[1
]}

Gupta, V. K. ^{[3
]}

Singh, Prashant ^{[4
]}

Negi, Uma ^{[4
]}

机构：

[1] Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmaceut & Drug Ind Res Div, Cairo 12311, Egypt

[2] Jamia Millia Islamia, Dept Chem, New Delhi, India

[3] Indian Inst Technol, Dept Chem, Roorkee, Uttar Pradesh, India

[4] Post Grad PG Coll, DAV, Dept Chem, Dehra Dun, Uttar Pradesh, India

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 10期

关键词：

Biological samples; chloramphenicol; HPLC analysis; nanodetection; LIQUID-CHROMATOGRAPHIC DETERMINATION; SOLID-PHASE EXTRACTION; MOLECULARLY IMPRINTED POLYMER; LC-ESI-MS/MS; GAS-CHROMATOGRAPHY; CONFIRM CHLORAMPHENICOL; FOOD-PRODUCTS; DRUG RESIDUES; MUSCLE-TISSUE; MILK;

D O I：

10.1080/00032710902954482

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chloramphenicol (CAP) is the drug of choice for the treatment of typhoid fever and other diseases and is consumed by millions of people. Chloramphenicol is a broad-spectrum antibiotic, but it has serious side effects and high risk of anemia if taken continuously. The drug persists for a long time in the human body and is likely to damage to the liver, kidneys, and red blood cells, even at low concentrations. From the human health point of view, analysis of low levels of this drug in biological samples is important. This article present an overview of the analysis of CAP in biological samples by high-performance liquid chromatography (HPLC). In addition, the available methods are compared in terms of their applications, efficiencies, and effectiveness.

引用

页码：1368 / 1381

页数：14

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