Chemical and preclinical studies on Hedyotis diffusa with anticancer potential

被引：77

作者：

Niu, Yu ^{[1
]}

Meng, Qiu-Xia ^{[2
]}

机构：

[1] Shanxi Acad Agr Sci, Inst Agr Resources & Econ, Taiyuan 030006, Peoples R China

[2] Shanxi Acad Agr Sci, Inst Agr Environm & Resources, Taiyuan 030006, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2013年 / 15卷 / 05期

关键词：

Rubiaceae; Hedyotis diffusa; constituents; cancer; preclinical; P-COUMARIC ACID; URSOLIC ACID; OLDENLANDIA-DIFFUSA; BETA-SITOSTEROL; OLEANOLIC ACID; CANCER CELLS; INHIBITORY-ACTIVITY; IRIDOID GLUCOSIDES; WILLD EXTRACT; FERULIC ACID;

D O I：

10.1080/10286020.2013.781589

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

This paper presents the chemical and preclinical anticancer research on Hedyotis diffusa Willd. in detail, one of the most renowned herbs often prescribed in the polyherbal formulas for cancer treatment in traditional Chinese medicine. Anthraquinones, flavonoids, and terpenoids constitute the majority of the 69 compounds that have been isolated and identified from H. diffusa. The anticancer effects of the methanolic, ethanolic, and aqueous extracts in various preclinical cancer models have been described. This review also summarized the anticancer activity of constituents of the herb and the mechanisms of action. All the studies suggest that H. diffusa has enormous potential in the therapy of cancer and warrants further chemical and pharmacological investigation.

引用

页码：550 / 565

页数：16

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