Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

被引：1113

作者：

Augustin, Hellmut G. ^{[1
,2
]}

Koh, Gou Young ^{[3
,4
]}

Thurston, Gavin ^{[5
]}

Alitalo, Kari ^{[6
]}

机构：

[1] Heidelberg Univ, Joint Res Div Vasc Biol, Med Fac Mannheim CBTM, D-6900 Heidelberg, Germany

[2] DKFZ ZMBH Alliance, German Canc Res Ctr Heidelberg, Heidelberg, Germany

[3] Korea Adv Inst Sci & Technol, Natl Res Lab Vasc Biol, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Biomed Res Ctr, Dept Biol Sci, Taejon 305701, South Korea

[5] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

[6] Univ Helsinki, Biomedicum, Lab Mol Canc Biol, Dept Pathol,Haartman Inst, Helsinki 00014, Finland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 03期

基金：

美国国家卫生研究院; 芬兰科学院;

关键词：

RECEPTOR-TYROSINE KINASE; ENDOTHELIAL-CELL SURVIVAL; TUMOR ANGIOGENESIS; BLOOD-VESSELS; LIGAND ANGIOPOIETIN-2; INHIBITS ANGIOGENESIS; MOLECULAR REGULATION; MESSENGER-RNA; GROWTH; EXPRESSION;

D O I：

10.1038/nrm2639

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls embryonic development and is also involved in numerous life-threatening human diseases. Much work in the field of angiogenesis research has centred on the vascular endothelial growth factor (VEGF)-VEGF receptor system. The Tie receptors and their angiopoietin (Ang) ligands have been identified as the second vascular tissue-specific receptor Tyr kinase system. Ang-Tie signalling is essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands provide unique insights into the functions of this vascular signalling system.

引用

页码：165 / 177

页数：13

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