Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O

被引：110

作者：

Sajiki, H ^{[1
]}

Aoki, F ^{[1
]}

Esaki, H ^{[1
]}

Maegawa, T ^{[1
]}

Hirota, K ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol0496374

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and extensive deuterium incorporation using heterogeneous Pd/C-D2O-H-2 system into many different types of unactivated C-H bond positions was developed. The present method provides a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D2O media.

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页码：1485 / 1487

页数：3

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