Effects of serotonin on different patterns of low Mg2+-induced epileptiform activity in the subiculum of rats studied in vitro

被引：5

作者：

Behr, J

Heinemann, U

机构：

[1] Inst. of Physiol. at the Charite, Department of Neurophysiology, Humboldt University Berlin, 10117 Berlin, Tucholskystr

来源：

BRAIN RESEARCH | 1996年 / 737卷 / 1-2期

关键词：

subiculum; seizure-like events; late recurrent discharge; low magnesium; membrane-potential change; field potential; 5-HT;

D O I：

10.1016/0006-8993(96)00946-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The subiculum is an epilepsy-prone area within the hippocampal complex that receives a dense serotonergic innervation from the raphe nuclei. We investigated the effect of 5-HT on epileptiform activity in this region with intra- and extracellular recordings. Our data suggest that 5-HT has predominately inhibitory effects on epileptiform activity in the subiculum but in some cases could also function as a disinhibitory agent. As the subiculum is an important output station of the hippocampal complex the serotonergic innervation might influence the spread of epileptic seizures.

引用

页码：331 / 334

页数：4

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