Effect of acute L-dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease

被引:19
作者
Mandel, RJ [1 ]
机构
[1] Univ Florida, Coll Med, Inst Brain, Dept Neurosci, Gainesville, FL 32610 USA
关键词
dopamine; nigrostriatal tract; striatum; 6-hydroxydopamine; receptor supersensitivity;
D O I
10.1006/exnr.1999.7245
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Currently, reduction of apomorphine-induced rotational behavior in the B-hydroxydopamine (6-OHDA) lesioned rat is the most utilized drug-induced paradigm for assessing functional efficacy in a rat model of Parkinson's disease (PD). Any clinically predictive animal model of PD should include a positive response to L-dopa, the standard pharmacotherapy for PD. However, the acute interaction between L-dopa and apomorphine has never been studied to determine if L-dopa pretreatment could reduce apomorphine-induced rotational behavior in a 6-OHDA lesioned rat. The present study was designed to explore whether, indeed, pretreatment with subrotational doses of L-dopa could inhibit apomorphine-induced rotations. The data indicate that L-dopa significantly reduced apomorphine-induced rotational behavior only at one dose (5.0 mg/kg) for 12 min. Based on these and other data, it is concluded that although the apomorphine-induced rotational paradigm may continue to be utilized as one additional indicator of efficacy in the 6-OHDA rat model of PD, it is not in itself a completely valid functional assay. (C) 2000 Academic Press.
引用
收藏
页码:212 / 219
页数:8
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