Multiple roles of canonical Wnt signaling in cell cycle progression and cell lineage specification in neural development

被引：30

作者：

Sommer, L ^{[1
]}

机构：

[1] ETH Honggerberg, Swiss Fed Inst Technol, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

CELL CYCLE | 2004年 / 3卷 / 06期

关键词：

Wnt; beta-catenin; neural stem cell; neural crest; sensory neuron; cell cycle; fate decision;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Signaling by the canonical Wnt pathway has multiple functions in stem cells. It can either control stem cell expansion or-as we have recently demonstrated with neural crest stem cells-influence cell lineage decisions by promoting specific fates at the expense of others. Thus, the role of canonical Wnt in stem cells is dependent on cell-intrinsic properties that determine how a cell responds to Wnt. The molecular basis for the functional diversity of Wnt in different stem cell types remains to be elucidated.

引用

页码：701 / 703

页数：3

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