Brominated hydroxyquinoline as a photolabile protecting group with sensitivity to multiphoton excitation

被引：100

作者：

Fedoryak, OD ^{[1
]}

Dore, TM ^{[1
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 20期

关键词：

D O I：

10.1021/ol026524g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and photochemistry of a new photolabile protecting group for carboxylic acids based on 8-bromo-7-hydroxyquinoline (BHQ) is described. BHQ possesses a greater single photon quantum efficiency than 4,5-dimethoxy-4-nitrobenzyl ester (DMNB) and 6-bromo-7hydroxycoumarin-4-ylmethyl (Bhc), and it has sufficient sensitivity to multiphoton-induced photolysis for use in vivo. Its increased solubility and low fluorescence make it quite useful as a caging group for biological messengers.

引用

页码：3419 / 3422

页数：4

共 37 条

[1]

ADAMS SR, 1993, ANNU REV PHYSIOL, V55, P755, DOI 10.1146/annurev.physiol.55.1.755

[2] BIOLOGICALLY USEFUL CHELATORS THAT RELEASE CA-2+ UPON ILLUMINATION [J].