Sperm quality may adversely affect the chromosome constitution of embryos that result from intracytoplasmic sperm injection

被引:28
作者
Obasaju, M
Kadam, A
Sultan, K
Fateh, M
Munné, S
机构
[1] New York Fertil Inst, New York, NY 10028 USA
[2] St Barnabas Hosp, Inst Reprod Med & Sci, Livingston, NJ USA
关键词
embryo biopsy; PGD; mosaicism; embryo quality;
D O I
10.1016/S0015-0282(99)00391-X
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine whether the high rate of chromosomal abnormalities in the embryos of an infertile couple were caused by a paternal factor that may have involved the sperm centriole. Design: Case report. Setting: Private IVF program. Patient(s): An infertile couple who underwent IVF-ET because of severe male factor infertility and endometriosis. Intervention(s): Preimplantation genetic diagnosis of chromosomal abnormalities in embryos derived from two cycles of ICSI in which the husband's sperm was used and one in which donor sperm was used. Main Outcome Measure(s): Preimplantation genetic diagnosis with fluorescence in situ hybridization using probes for chromosomes X, Y, 13, 16, 18, and 21, and determination of hCG levels. Result(s): Most of the embryos derived from the cycles in which the husband's sperm was used were chromosomally abnormal (82%), whereas all the embryos derived from the cycle in which donor sperm was used were chromosomally normal. The cycle in which donor sperm was used resulted in an ongoing pregnancy. Conclusion(s): Paternal factors, which most likely derive from the centrosome, can contribute to numerical chromosomal abnormalities, which in turn may predispose to implantation failure. (Fertil Steril(R) 1999;72: 1113-5. (C) 1999 by American Society for Reproductive Medicine).
引用
收藏
页码:1113 / 1115
页数:3
相关论文
共 6 条
[1]   The centrosome - a tiny organelle with big potential [J].
Doxsey, S .
NATURE GENETICS, 1998, 20 (02) :104-106
[2]   Evidence that oligoasthenozoospermia may be an etiologic factor for spontaneous abortion after in vitro fertilization-embryo transfer [J].
Kiefer, D ;
Check, JH ;
Katsoff, D .
FERTILITY AND STERILITY, 1997, 68 (03) :545-548
[3]  
MARTIN RH, 1995, AM J HUM GENET, V57, P1395
[4]   Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21 [J].
Munne, S ;
Marquez, C ;
Magli, C ;
Morton, P ;
Morrison, L .
MOLECULAR HUMAN REPRODUCTION, 1998, 4 (09) :863-870
[5]   Chromosome abnormalities in human embryos [J].
Munné, S ;
Cohen, J .
HUMAN REPRODUCTION UPDATE, 1998, 4 (06) :842-855
[6]   Fate of the sperm mitochondria, and the incorporation, conversion, and disassembly of the sperm tail structures during bovine fertilization [J].
Sutovsky, P ;
Navara, CS ;
Schatten, G .
BIOLOGY OF REPRODUCTION, 1996, 55 (06) :1195-1205