Sequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression

被引：28

作者：

Williams, JR

Thayyullathil, C

Freitag, NE

机构：

[1] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA

[2] Publ Hlth Res Inst, New York, NY USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 03期

关键词：

D O I：

10.1128/JB.182.3.837-841.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Reporter gene fusions were used to investigate the contributions of PrfA DNA binding sites to Listeria monocytogenes virulence gene expression. Our results suggest that the DNA sequence of PrfA binding sites determines the levels of expression of certain virulence genes, such as hly and mpl. Other virulence genes, such as actA and plcB, may depend upon additional factors for full regulation of gene expression.

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页码：837 / 841

页数：5

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