Synthesis of new glycosylated neutral and cationic porphyrin dimers

被引：22

作者：

Kaldapa, C

Blais, JC

Carré, V

Granet, R

Sol, V

Guilloton, M

Spiro, M

Krausz, P

机构：

[1] Univ Limoges, Lab Chim Subst Nat, F-87060 Limoges, France

[2] Univ Paris 06, Lab Chim Organ Struct & Biol, CNRS, F-75005 Paris, France

[3] Univ Limoges, Inst Biotechnol, F-87060 Limoges, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(99)02085-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and characterisation of symmetrical glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain to improve targeting on malignant cells is reported. Photocytotoxicity of these compounds against the K562 leukemia cell line compared to the effect of hematoporphyrin is also presented. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：331 / 335

页数：5

相关论文

共 24 条

[1] ATROPISOMER-SPECIFIC FORMATION OF PREMICELLAR PORPHYRIN J-AGGREGATES IN AQUEOUS SURFACTANT SOLUTIONS [J].

BARBER, DC ;

FREITAGBEESTON, RA ;

WHITTEN, DG .

JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (10) :4074-4086

[2]

Dougherty T. J., 1984, PORPHYRIN LOCALIZATI, P301

[3] Synthesis of glycosylated cationic porphyrins as potential agents in photodynamic therapy [J].

Driaf, K ;

Granet, R ;

Krausz, P ;

Kaouadji, M ;

Thomasson, F ;

Chulia, AJ ;

Verneuil, B ;

Spiro, M ;

Blais, JC ;

Bolbach, G .

CANADIAN JOURNAL OF CHEMISTRY, 1996, 74 (08) :1550-1563

[4] LINKED PORPHYRIN SYSTEMS [J].

FLEISCHER, EB ;

SHACHTER, AM .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (07) :1693-1699

[5] CHIRAL MICELLAR PORPHYRIN FIBERS WITH 2-AMINOGLYCOSAMIDE HEAD GROUPS [J].

FUHRHOP, JH ;

DEMOULIN, C ;

BOETTCHER, C ;

KONING, J ;

SIGGEL, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (11) :4159-4165

[6] Synthesis and structural analysis of novel meso-glycosyarylprophyrins for application to oncological phototherapy [J].

Gaud, O ;

Granet, R ;

Kaouadji, M ;

Krausz, P ;

Blais, JC ;

Bolbach, G .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1996, 74 (04) :481-499

[7] ORTHO-(DIFLUOROMETHYL)ARYL-BETA-D-GLUCOSIDES AND PARA-(DIFLUOROMETHYL)ARYL-BETA-D-GLUCOSIDES - A NEW CLASS OF ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF BETA-GLUCOSIDASES [J].

HALAZY, S ;

BERGES, V ;

EHRHARD, A ;

DANZIN, C .

BIOORGANIC CHEMISTRY, 1990, 18 (03) :330-344

[8] A COMPARATIVE-STUDY OF THE INTERACTION OF 5,10,15,20-TETRAKIS (N-METHYLPYRIDINIUM-4-YL)PORPHYRIN AND ITS ZINC COMPLEX WITH DNA USING FLUORESCENCE SPECTROSCOPY AND TOPOISOMERIZATION [J].

KELLY, JM ;

MURPHY, MJ ;

MCCONNELL, DJ ;

OHUIGIN, C .

NUCLEIC ACIDS RESEARCH, 1985, 13 (01) :167-184

[9]

KESSEL D, 1987, CANCER RES, V47, P4642

[10]

KIEDA C, 1986, INVAS METAST, V6, P347