Hypoglycaemic effect of Helicteres isora bark extract in rats

被引：32

作者：

Kumar, G.

Banu, G. Sharmila

Murugesan, A. G.

Pandian, M. Rajasekara ^{[1
]}

机构：

[1] Muthayammal Coll Arts & Sci, Ctr Biotechnol, Namakkal 637408, Tamil Nadu, India

[2] Manonmaniam Sundaranar Univ, Sri Paramakalyani Ctr Environm Sci, Alwarkurichi 627412, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 107卷 / 02期

关键词：

Helicteres isora (Sterculiaceae); streptozotocin; blood glucose levels; hypoglycaemic effect;

D O I：

10.1016/j.jep.2006.05.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycaemic effect of the aqueous extract of the bark of Helicteres isora L. (Sterculiaceae) was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the bark of Helicteres isora L. (100 and 200 mg/kg/p.o.) significantly (P < 0.001) reduced the blood glucose levels from 64.5-48.5 and 67-47 mg% 2 h after oral administration of bark extract and also significantly lowered the blood glucose in STZ diabetic rats from 68-105 and 66-85.5 mg% 21 days after daily oral administration of the extract (P < 0.001). The results suggested that the aqueous extract of bark of Helicteres isora L. possesses a potential hypoglycaemic effect in diabetic rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：304 / 307

页数：4

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