Boswellic acids in chronic inflammatory diseases

被引：243

作者：

Ammon, H. P. T. ^{[1
]}

机构：

[1] Univ Tubingen, Dept Pharmacol, Inst Pharmaceut Sci, D-72076 Tubingen, Germany

来源：

PLANTA MEDICA | 2006年 / 72卷 / 12期

关键词：

boswellic acids; anti-inflammatory actions; immune system; leukotrienes; chronic bowel diseases; arthritis; bronchial asthma;

D O I：

10.1055/s-2006-947227

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Oleogum resins from Boswellia species are used in traditional medicine in India and African countries for the treatment of a variety of diseases. Animal experiments showed anti-inflammatory activity of the extract. The mechanism of this action is due to some boswellic acids. It is different from that of NSAID and is related to components of the immune system. The most evident action is the inhibition of 5-lipoxygenase. However, other factors such as cytokines (interleukins and TNF-alpha) and the complement system are also candidates. Moreover, leukocyte elastase and oxygen radicals are targets. Clinical studies, so far with pilot character, suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma. Side effects are not severe when compared to modern drugs used for the treatment of these diseases.

引用

页码：1100 / 1116

页数：17

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