Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007

被引：95

作者：

Mizuta, K. ^{[1
]}

Aoki, Y. ^{[1
]}

Suto, A. ^{[1
]}

Ootani, K. ^{[1
]}

Katsushima, N. ^{[2
]}

Itagaki, T. ^{[3
]}

Ohmi, A. ^{[4
]}

Okamoto, M. ^{[4
]}

Nishimura, H. ^{[4
]}

Matsuzaki, Y. ^{[5
]}

Hongo, S. ^{[6
]}

Sugawara, K. ^{[6
]}

Shimizu, H. ^{[7
]}

Ahiko, T. ^{[1
]}

机构：

[1] Yamagata Prefectural Inst Publ Hlth, Dept Microbiol, Yamagata 9900031, Japan

[2] Katsushima Pediat Clin, Yamagata 9902461, Japan

[3] Yamanobe Pediat Clin, Yamagata 9900301, Japan

[4] Sendai Medial Ctr, Virus Res Ctr, Sendai, Miyagi 9838520, Japan

[5] Yamagata Univ, Course Clin Nursing, Fac Med, Yamagata 9909585, Japan

[6] Yamagata Univ, Dept Infect Dis, Fac Med, Yamagata 9909585, Japan

[7] Natl Inst Infect Dis, Dept Virol 2, Tokyo 2080011, Japan

来源：

VACCINE | 2009年 / 27卷 / 24期

关键词：

Enterovirus type 71; Subgenogroup; Cross-antigenicity; LETHAL ENTEROVIRUS-71 INFECTION; MOLECULAR EPIDEMIOLOGY; CYNOMOLGUS MONKEYS; MICROPLATE METHOD; NEWBORN MICE; EVOLUTION; PROTECTION; MALAYSIA; IMMUNIZATION; SINGAPORE;

D O I：

10.1016/j.vaccine.2009.03.060

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated and identified Six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also Suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against Other genotypes. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3153 / 3158

页数：6

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