Nanochemistry: Synthesis and characterization of multifunctional nanoclinics for biological applications

被引：281

作者：

Levy, L ^{[1
]}

Sahoo, Y ^{[1
]}

Kim, KS ^{[1
]}

Bergey, EJ ^{[1
]}

Prasad, PN ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA

来源：

CHEMISTRY OF MATERIALS | 2002年 / 14卷 / 09期

关键词：

D O I：

10.1021/cm0203013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This paper presents the use of nanoscale chemistry to synthesize a multilevel, hierarchically built nanoparticle, which we define as a nanoclinic, for targeted diagnostics and therapy. This nanoclinic, produced by multistep chemistry in a nanosize micelle, consists of a thin silica shell encapsulating magnetic (Fe2O3) nanoparticles and fluorescent dyes for enhanced contrast magnetic resonance and optical imaging and magnetic-induced cancer therapy. Furthermore, the surface of these prototype nanoclinics is functionalized with a biotargeting group, luteinizing hormone-releasing hormone (LH-RH). In the work reported here, the LH-RH targets receptor-specific cancer cells for utilization in imaging and investigation of biological effects. The structure and function of these nanoclinics have been characterized using electron and X-ray diffractions, transmission electron microscopy, atomic force and scanning electron microscopy and two-photon laser scanning microscopy. Targeting of the receptor-specific cells has been demonstrated, along with the demonstration of a new mechanism of selective destruction of cancer cells, in a dc magnetic field, using these magnetic nanoclinics.

引用

页码：3715 / 3721

页数：7

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