Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

被引：600

作者：

van Haaften, Gijs ^{[1
]}

Dalgliesh, Gillian L. ^{[1
]}

Davies, Helen ^{[1
]}

Chen, Lina ^{[1
]}

Bignell, Graham ^{[1
]}

Greenman, Chris ^{[1
]}

Edkins, Sarah ^{[1
]}

Hardy, Claire ^{[1
]}

O'Meara, Sarah ^{[1
]}

Teague, Jon ^{[1
]}

Butler, Adam ^{[1
]}

Hinton, Jonathan ^{[1
]}

Latimer, Calli ^{[1
]}

Andrews, Jenny ^{[1
]}

Barthorpe, Syd ^{[1
]}

Beare, Dave ^{[1
]}

Buck, Gemma ^{[1
]}

Campbell, Peter J. ^{[1
]}

Cole, Jennifer ^{[1
]}

Forbes, Simon ^{[1
]}

Jia, Mingming ^{[1
]}

Jones, David ^{[1
]}

Kok, Chai Yin ^{[1
]}

Leroy, Catherine ^{[1
]}

Lin, Meng-Lay ^{[1
]}

McBride, David J. ^{[1
]}

Maddison, Mark ^{[1
]}

Maquire, Simon ^{[1
]}

Mclay, Kirsten ^{[1
]}

Menzies, Andrew ^{[1
]}

Mironenko, Tatiana ^{[1
]}

Mulderrig, Lee ^{[1
]}

Mudie, Laura ^{[1
]}

Pleasance, Erin ^{[1
]}

Shepherd, Rebecca ^{[1
]}

Smith, Raffaella ^{[1
]}

Stebbings, Lucy ^{[1
]}

Stephens, Philip ^{[1
]}

Tang, Gurpreet ^{[1
]}

Tarpey, Patrick S. ^{[1
]}

Turner, Rachel ^{[1
]}

Turrell, Kelly ^{[1
]}

Varian, Jennifer ^{[1
]}

West, Sofie ^{[1
]}

Widaa, Sara ^{[1
]}

Wray, Paul ^{[1
]}

Collins, V. Peter ^{[2
]}

Ichimura, Koichi ^{[2
]}

Law, Simon ^{[3
]}

Wong, John ^{[3
]}

机构：

[1] Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[3] Univ Hong Kong, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China

[4] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

[5] Harvard Univ, Sch Med, Dana Farber Canc Inst, Belfer Inst Innovat Canc Sci,Dept Med Oncol,Ctr A, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dana Farber Canc Inst, Belfer Inst Innovat Canc Sci,Dept Med & Genet,Ctr, Boston, MA 02115 USA

[7] Dana Farber Canc Inst, Lebow Inst Myeloma Therapeut, Boston, MA 02115 USA

[8] Dana Farber Canc Inst, Lipper Myeloma Ctr, Boston, MA 02115 USA

[9] Spectrum Hlth Hosp, Dept Urol, Grand Rapids, MI USA

[10] Van Andel Inst, Canc Genet Lab, Grand Rapids, MI USA

[11] Inst Canc Res, Sutton, Surrey, England

来源：

NATURE GENETICS | 2009年 / 41卷 / 05期

关键词：

MYELOMA CELL-LINE; TARGET GENES; METHYLTRANSFERASE; JMJD3; MICE;

D O I：

10.1038/ng.349

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.

引用

页码：521 / 523

页数：3

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