Sphingosine 1-Phosphate A Regulator of Arterial Lesions

被引：62

作者：

Daum, G. ^{[2
]}

Grabski, A. ^{[1
,2
]}

Reidy, M. A. ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Surg, Seattle, WA 98195 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2009年 / 29卷 / 10期

关键词：

LYSOPHOSPHOLIPID RECEPTOR S1P(3); MUSCLE-CELL DIFFERENTIATION; PROTEIN-COUPLED RECEPTOR; GROWTH-FACTOR RECEPTOR; SPHINGOSINE-1-PHOSPHATE RECEPTORS; ENDOTHELIAL-CELLS; MOLECULAR-CLONING; FUNCTIONAL-CHARACTERIZATION; VASCULAR MATURATION; BARRIER INTEGRITY;

D O I：

10.1161/ATVBAHA.108.175240

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell functions. (Arterioscler Thromb Vasc Biol. 2009; 29: 1439-1443.)

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收藏

页码：1439 / 1443

页数：5

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