Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

被引：12

作者：

Bandarian, Vahe ^{[1
]}

Drennan, Catherine L. ^{[2
,3
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Dept Chem, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2015年 / 35卷

基金：

美国国家卫生研究院;

关键词：

TRANSFER-RNA TRANSGLYCOSYLASE; MODIFIED NUCLEOSIDE-Q; SAM ENZYME QUEE; FOLIC-ACID; GUANINE TRANSGLYCOSYLASE; LYSINE 2,3-AMINOMUTASE; S-ADENOSYLMETHIONINE; TOYOCAMYCIN; MOIETY; CYCLOHYDROLASE;

D O I：

10.1016/j.sbi.2015.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.

引用

收藏

页码：116 / 124

页数：9

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