Differential activation of STATs 3 and 5 during mammary gland development

被引：101

作者：

Philp, JAC ^{[1
]}

Burdon, TG ^{[1
]}

Watson, CJ ^{[1
]}

机构：

[1] ROSLIN INST,DIV MOL BIOL,ROSLIN EH25 9PS,MIDLOTHIAN,SCOTLAND

来源：

FEBS LETTERS | 1996年 / 396卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

STAT; mammary gland; apoptosis; signal transduction;

D O I：

10.1016/0014-5793(96)01069-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels, DNA binding complexes containing both STAT5a and 5b showed differing affinities for two naturally occurring STAT5 binding sites. In the involuting mammary gland STAT5 activity decreased whereas STAT3 was specifically activated. These observations reveal a complex pattern of activation of STAT factors during mammary growth, differentiation and remodelling and pro,ide the first evidence for the involvement of STAT3 in development of the mammary gland.

引用

页码：77 / 80

页数：4

共 18 条

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