Adult neurogenesis: mechanisms and functional significance

被引：133

作者：

Braun, Simon M. G. ^{[1
,2
,3
]}

Jessberger, Sebastian ^{[1
,2
,3
]}

机构：

[1] Univ Zurich, Fac Med & Sci, Brain Res Inst, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Neurosci Ctr Zurich, CH-8057 Zurich, Switzerland

[3] ETH, CH-8057 Zurich, Switzerland

来源：

DEVELOPMENT | 2014年 / 141卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

Neural stem cell; Neurogenesis; Neurons; Neuropsychiatric disease; NEURAL STEM-CELLS; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; PATTERN SEPARATION; OLFACTORY-BULB; HUMAN BRAIN; BORN NEURONS; ASTROCYTES; MICE; DIFFERENTIATION;

D O I：

10.1242/dev.104596

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an overview of the mechanisms governing the neurogenic process in the adult brain and describe how new neurons may contribute to brain function in health and disease.

引用

收藏

页码：1983 / 1986

页数：4

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