The influence of different combinations of γ-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects

被引:91
作者
Miles, EA
Banerjee, T
Dooper, MMBW
M'Rabet, L
Graus, YMF
Calder, PC
机构
[1] Univ Southampton, Sch Med, Inst Human Nutr, Southampton SO16 7PX, Hants, England
[2] Numico Res BV, NL-6700 AA Wageningen, Netherlands
基金
英国医学研究理事会;
关键词
cytokine; immunoglobulin; phagocytosis; respiratory burst;
D O I
10.1079/BJN20041131
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
To determine the effects of EPA, stearidonic acid (STA) or gamma-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2(.)0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20: 4n-3 appeared in PBMC when STA (<1.0 g/d) was consumed. However, STA (1(.)0 g/d), in combination with GLA (0(.)9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2(.)0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG(2) concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2(.)0g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1(.)0g/d does not affect human immune function.
引用
收藏
页码:893 / 903
页数:11
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