Modeling and prediction of cocrystal phase diagrams

被引：70

作者：

Ainouz, Abigail ^{[1
]}

Authelin, Jean-Rene ^{[1
]}

Billot, Pascal ^{[1
]}

Lieberman, Harvey ^{[2
]}

机构：

[1] Sanofi Aventis, Res & Dev, Phys Qual, F-94403 Vitry Sur Seine, France

[2] Sanofi Aventis, Res & Dev, Phys Qual, Bridgewater, NJ USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 374卷 / 1-2期

关键词：

Cocrystals; Crystal engineering; Pharmaceuticals; Phase diagram; Solubility; Thermodynamics; CO-CRYSTALS; COMPOUND; IMPROVE; UTILITY;

D O I：

10.1016/j.ijpharm.2009.03.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this paper, a new approach to model cocrystal phase diagrams is presented. Starting from an initial set of data, the phase diagram is obtained from discontinuous isoperibolic thermal analysis (DITA) and basic thermodynamic data (enthalpies and solubilities). The solubility product constant may then be determined. Since this constant is solvent independent, extrapolation to other solvents is possible. Application of this technique to an active pharmaceutical ingredient and glutaric acid demonstrates good agreement between calculated and experimental data. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：82 / 89

页数：8

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