Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways

被引：15

作者：

Kurosawa, Tamaki ^{[1
,2
]}

Yamada, Atsushi ^{[1
]}

Takami, Masamichi ^{[3
]}

Suzuki, Dai ^{[1
]}

Saito, Yoshiro ^{[1
,4
]}

Hiranuma, Katsuhiro ^{[1
,5
]}

Enomoto, Takuya ^{[1
,6
]}

Morimura, Naoko ^{[7
]}

Yamamoto, Matsuo ^{[6
]}

Iijima, Takehiko ^{[5
]}

Shirota, Tatsuo ^{[4
]}

Itabe, Hiroyuki ^{[2
]}

Kamijo, Ryutaro ^{[1
]}

机构：

[1] Showa Univ, Sch Dent, Dept Biochem, Shinagawa Ku, Tokyo 1428555, Japan

[2] Showa Univ, Sch Pharm, Dept Mol Biol, Div Biol Chem,Shinagawa Ku, Tokyo 1428555, Japan

[3] Showa Univ, Sch Dent, Dept Pharmacol, Ohta, Tokyo 1458515, Japan

[4] Showa Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Ohta, Tokyo 1458515, Japan

[5] Showa Univ, Sch Dent, Dept Perioperat Med, Div Anesthesiol, Ohta, Tokyo 1458515, Japan

[6] Showa Univ, Sch Dent, Dept Periodontol, Ohta, Tokyo 1458515, Japan

[7] Ritsumeikan Univ, Res Org Sci & Technol, Brain Sci Lab, Kusatsu, Shiga 5258577, Japan

来源：

FEBS OPEN BIO | 2015年 / 5卷

基金：

日本学术振兴会;

关键词：

Nephronectin; Oncostatin M; JAK/STAT; MAPK; OSTEOBLAST DIFFERENTIATION; PROTEIN NEPHRONECTIN; POEM; ACTIVATION; CYTOKINES;

D O I：

10.1016/j.fob.2015.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nephronectin (Npnt), also called POEM, is an extracellular matrix protein considered to play critical roles as an adhesion molecule in the development and functions of various tissues, such as the kidneys, liver, and bones. In the present study, we examined the molecular mechanism of Npnt gene expression and found that oncostatin M (OSM) strongly inhibited Npnt mRNA expression in MC3T3-E1 cells from a mouse osteoblastic cell line. OSM also induced a decrease in Npnt expression in both time-and dose-dependent manners via both the JAK/STAT and MAPK pathways. In addition, OSM-induced inhibition of osteoblast differentiation was recovered by over-expression of Npnt. These results suggest that OSM inhibits Npnt expression via the JAK/STAT and MAPK pathways, while down-regulation of Npnt by OSM influences inhibition of osteoblast differentiation. (C) 2015 The Authors. Published by Elsevier B.V.

引用

页码：303 / 307

页数：5

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