Acyl-coenzyme A: cholesterol acyltransferases

被引：369

作者：

Chang, Ta-Yuan ^{[1
]}

Li, Bo-Liang ^{[2
]}

Chang, Catherine C. Y. ^{[1
]}

Urano, Yasuomi ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai, Peoples R China

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2009年 / 297卷 / 01期

关键词：

acyl-coenzyme A: cholesterol acyltransferase inhibitors; atherosclerosis; Alzheimer's disease; MONOCYTE-DERIVED MACROPHAGES; HAMSTER OVARY CELLS; E-DEFICIENT MICE; ISOFORM-SPECIFIC INHIBITOR; 2 DIFFERENT CHROMOSOMES; ACAT INHIBITOR; IN-VITRO; ATHEROSCLEROTIC LESIONS; ENDOPLASMIC-RETICULUM; ALZHEIMERS-DISEASE;

D O I：

10.1152/ajpendo.90926.2008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chang TY, Li BL, Chang CC, Urano Y. Acyl-coenzyme A: cholesterol acyltransferases. Am J Physiol Endocrinol Metab 297: E1-E9, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90926.2008.-The enzymes acylcoenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.

引用

页码：E1 / E9

页数：9

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