Medulloblastoma: Molecular Classification-Based Personal Therapeutics

被引：80

作者：

Archer, Tenley C. ^{[1
,2
]}

Mahoney, Elizabeth L. ^{[1
]}

Pomeroy, Scott L. ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

NEUROTHERAPEUTICS | 2017年 / 14卷 / 02期

关键词：

Medulloblastoma; WHO; MYC; SHH; WNT; Genomic; DNA methylation; Subgroups; Group; 3; 4; CENTRAL-NERVOUS-SYSTEM; CRANIOSPINAL RADIATION-THERAPY; ADJUVANT CHEMOTHERAPY; CHILDHOOD MEDULLOBLASTOMA; RISK MEDULLOBLASTOMA; GERMLINE MUTATION; WNT/BETA-CATENIN; RANDOMIZED-TRIAL; TP53; MUTATION; CANCER;

D O I：

10.1007/s13311-017-0526-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Recent advances in cancer genomics have revealed 4 distinct subgroups of medulloblastomas, each with unique transcription profiles, DNA alterations and clinical outcome. Molecular classification of medulloblastomas improves predictions of clinical outcome, allowing more accurate matching of intensity of conventional treatments with chemotherapy and radiation to overall prognosis and setting the stage for the introduction of targeted therapies.

引用

页码：265 / 273

页数：9

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