Eukaryotic translation termination factor gene (ETF1/eRF1) maps at D5S500 in a commonly deleted region of chromosome 5q31 in malignant myeloid diseases

被引：7

作者：

Guenet, L

Henry, C

Toutain, B

Dubourg, C

Le Gall, JY

David, V

Le Treut, A

机构：

[1] Fac Med, Dept Biochim & Biol Mol, Biochim Lab A, F-35043 Rennes, France

[2] Fac Med, CNRS, UPR41, F-35043 Rennes, France

[3] CHRU Pontchaillou, Serv Cytogenet & Biol Cellulaire, Rennes, France

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 88卷 / 1-2期

关键词：

D O I：

10.1159/000015491

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The human genome contains four ETE1 (eukaryotic translation termination factor 1) homologous sequences, Idealized on chromosomes 5, 6, 7 and X, and corresponding to a functional gene an chromosome 5 and three processed pseudogenes on the other chromosomes. ETF1 genomic or cDNA probes were mapped by fluorescence in situ hybridization to 5q31, 6p21, 7q11 and Xp11.4-->p11.1. A microsatellite marker (D5S500) was identified in intron 7 of the functional ETF1 gene providing its exact position in the 5q31 band. Thus, the ETF1 gene is located in a 5q region which contains unidentified genes responsible for genetic or malignant disorders, and it might be considered as a candidate gene involved in the pathogenesis of these diseases. Copyright (C) 2000 S.Karger AG, Basel.

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页码：82 / 86

页数：5

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