Rapid engraftment after allogeneic ABO-incompatible peripheral blood progenitor cell transplantation complicated by severe hemolysis

被引:32
作者
Bornhauser, M
Ordemann, R
Paaz, U
Schuler, U
Kompf, J
Holig, K
Ehninger, G
机构
[1] CARL GUSTAV CARUS UNIV,DEPT HEMATOL ONCOL,DRESDEN,GERMANY
[2] CARL GUSTAV CARUS UNIV,DEPT TRANSFUS MED,DRESDEN,GERMANY
[3] UNIV TUBINGEN,INST ANTHROPOL & GENET,TUBINGEN,GERMANY
关键词
allogeneic PBPCT; ABO incompatibility; hemolysis; passenger lymphocytes;
D O I
10.1038/sj.bmt.1700641
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A patient with CML in accelerated phase received G-CSF-mobilized PBPC from an unrelated HLA genotypically matched donor, The blood groups of the patient and donor were bidirectionally incompatible. Hematologic recovery was rapid with >500 PMN/mu l on day +9, Starting on day +5 bilirubin levels increased from 1.3 mg/dl up to a maximum of 18 mg/dl on day +14. Clinical signs and laboratory tests supported major hemolysis, Blood typing on day +16 revealed early blood-group change, consistent with donor-derived antibodies produced by passenger-lymphocytes which may have mediated severe hemolysis. The early onset and strong intensity of the hyperbilirubinemia could be a specific feature of ABO-incompatible allogeneic PBPC transplantation which would be difficult to differentiate from GVHD or VOD.
引用
收藏
页码:295 / 297
页数:3
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