Asymmetric synthesis of erythro- and threo-2-(1-hydroxyalkyl)piperidines via iodocyclocarbamation of 1-acyl-2-alkenyl-1,2,3,6-tetrahydropyridines

被引：43

作者：

Comins, DL ^{[1
]}

Williams, AL ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 16期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

asymmetric synthesis; pyridinium salts; dihydropyridones; alkaloids; iodocyclocarbamation;

D O I：

10.1016/S0040-4039(00)00298-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iodocyclocarbamation procedure has been developed for the stereoselective preparation of erythro- and threo-2(1-hydroxyalkyl)piperidines. This methodology was utilized in the asymmetric synthesis of two piperidine alkaloids, (+)-alpha-conhydrine and (+)-beta-conhydrine. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2839 / 2842

页数：4

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