Role of discs large homolog 5

被引：28

作者：

Friedrichs, Frauke ^{[1
]}

Stoll, Monika ^{[1
]}

机构：

[1] Univ Munster, Leibniz Insr Arteriorsclerosis Res, D-48149 Munster, Germany

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 23期

关键词：

DLG5; association; gender; genetic heterogeneity; inflammatory bowel disease; Crohn disease;

D O I：

10.3748/wjg.v12.i23.3651

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples([1]). The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions. (c) 2006 The WJG Press. All rights reserved.

引用

页码：3651 / 3656

页数：6

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